Srikkanth Balasubramanian_2.jpg

DR. SRIKKANTH BALASUBRAMANIAN

Postdoctoral researcher – Delft University of Technology, The Netherlands

[email protected]

[email protected]


Supervisor

Prof. Dr. Elvin Karana

Dr. Marie-Eve Aubin-Tam

Srikkanth is a Microbiologist who hails from India. He finished his Bachelors of Technology in Industrial Biotechnology from SASTRA University in India. After his undergraduate studies, he was awarded the Graduate School of Life Sciences (GSLS) Fellowship by the German Excellence Initiative at the University of Wuerzburg in Germany to pursue doctoral research in Microbiology. In his doctoral thesis, he evaluated the anti-infective potential of marine sponge-associated actinomycetes against drug-resistant staphylococci and enterohemorrhagic Escherichia coli.

Following his PhD, Srikkanth moved to TU Delft to carry out his postdoctoral research on 3D bioprinting of bacteria and microalgae for the fabrication of living materials that are sustainable and possess defined functionalities. Currently, he has been working on the development of photosynthetic living materials that are circular in nature.


Current Project

3D BIOPRINTING FOR FABRICATION OF PHOTOSYNTHETIC LIVING MATERIALS

This project aims to create self-standing living functional materials employing 3D bioprinting technology. The unicellular microalgae Chlamydomonas reinhardtii that is capable of performing photosynthesis are bioprinted on a mechanically robust and sustainable raw material like bacterial cellulose for fabrication of photosynthetic living materials.

Photosynthetic living materials fully composed of microalgae and bacterial cellulose could convert atmospheric carbon dioxide and pollutants to oxygen and biomass just like plants and trees. The fabricated photosynthetic living materials are expected to reduce the carbon footprints in the planet much efficiently than plants in shorter periods of time.


PUBLICATIONS

  1. Balasubramanian, S. #, Yu, K. #, Meyer, A.S., Karana, E., & Aubin-Tam, M.E. (2021). Bioprinting of regenerative photosynthetic living materials. Adv Funct Mater, In press (#equally contributing authors)

  2. Yu, K., Balasubramanian, S., Pahlavani, H., Mirzaali, M. J., Zadpoor, A. A., & Aubin-Tam, M. E. (2020). Spiral honeycomb microstructured bacterial cellulose for increased strength and toughness. ACS Appl Mater Interfaces, 12(45), 50748-50755. doi:10.1021/acsami.0c15886

  3. Balasubramanian, S., Aubin-Tam, M. E., & Meyer, A. S. (2019). 3D printing for the fabrication of biofilm-based functional living materials. ACS Synth Biol, 8(7), 1564-1567. doi:10.1021/acssynbio.9b00192

  4. Balasubramanian, S., Skaf, J., Holzgrabe, U., Bharti, R., Forstner, K. U., Ziebuhr, W., Humeida, U.H., Abdelmohsen, U.R., & Oelschlaeger, T. A. (2018). A new bioactive compound from the marine sponge-derived Streptomyces sp. SBT348 inhibits staphylococcal growth and biofilm formation. Front Microbiol, 9, 1473. doi:10.3389/fmicb.2018.01473

  5. Skaf, J., Hamarsheh, O., Berninger, M., Balasubramanian, S., Oelschlaeger, T. A., & Holzgrabe, U. (2018). Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia, 125, 191-198. doi:10.1016/j.fitote.2017.11.001

  6. Cheng, C.#, Balasubramanian, S.#, Fekete, A., Krischke, M., Mueller, M. J., Hentschel, U., Oelschlaeger, T. A., & Abdelmohsen, U. R. (2017). Inhibitory potential of strepthonium A against Shiga toxin production in enterohemorrhagic Escherichia coli (EHEC) strain EDL933. Nat Prod Res, 31(23), 2818-2823. doi:10.1080/14786419.2017.1297443 (#equally contributing authors)

  7. Balasubramanian, S., Othman, E. M., Kampik, D., Stopper, H., Hentschel, U., Ziebuhr, W., Oelschlaeger, T. A., & Abdelmohsen, U. R. (2017). Marine sponge-derived Streptomyces sp. SBT343 extract inhibits staphylococcal biofilm formation. Front Microbiol, 8, 236. doi:10.3389/fmicb.2017.00236

  8. Abdelmohsen, U. R., Balasubramanian, S., Oelschlaeger, T. A., Grkovic, T., Pham, N. B., Quinn, R. J., & Hentschel, U. (2017). Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections. Lancet Infect Dis, 17(2), e30-e41. doi:10.1016/S1473-3099(16)30323-1

  9. Abdelmohsen, U. R., Grkovic, T., Balasubramanian, S., Kamel, M. S., Quinn, R. J., & Hentschel, U. (2015). Elicitation of secondary metabolism in actinomycetes. Biotechnol Adv, 33(6 Pt 1), 798-811. doi:10.1016/j.biotechadv.2015.06.003

  10. Hema, M., Balasubramanian, S., & Princy, S. A. (2015). Meddling Vibrio cholerae murmurs: a neoteric advancement in Cholera research. Indian J Microbiol, 55(2), 121-130. doi:10.1007/s12088-015-0520-1